The central defender scored the only goal of the game when Lido scalped the Steelmen in the third round of the cup at the start of December but is suspended.
"We will miss Carl who has been terrific for us all season, but we have to learn to cope and I feel we have the players that can do that," Lido manager Andrew Dyer told the South Wales Evening Post.
And Dyer is also concerned how last week's postponement at Bala will affect his men.
"We had real momentum going and I am hoping that not being in action last week will not upset our rhythm," he added.
"I don't think it will, but with the Christmas period also upon us preparation is more difficult. Hopefully, it will not be a massive problem.
"We have shown lots of guts and character and we need to keep the improvement, which has brought us four wins and a draw in five matches, going."
Meanwhile, Talbot are in a poor run of form that has yielded just one point from the last five games, but are boosted by the return of five players from suspension and injury.
Defenders Paul Keddle and Paul Cochlin together with midfielder Gareth Phillips return from suspensions while central defender Kye Edwards and goalkeeper Kristian Rogers are fit again.
"It's a great boost having five back, the cup match was very close and I expect this one to be equally tight, but we are capable of starting to turn the corner," said Port Talbot boss Mark Jones.
"We have 22 games left and if we could win seven or eight we can still finish seventh and have a chance of qualifying for Europe."