Manager Andrew Dyer is confident that a local derby in front of live S4C cameras will stir his players to produce their first derby win against the Steelmen.
"They are really up for this one and looking forward to it," he said.
"I'm sure it will be a game of passion and it is vital that we retain our discipline and concentration.
"It's an important match for both teams, as if Port Talbot win they would leapfrog us into fourth spot.
"It would also add pressure to the return game on New Year's Day. Port Talbot are a tough team to play against and I tipped them to be up there challenging for the top three at the start of the season."
Veteran Eagles' striker Carl Shaw is ruled-out and will miss the rest of the season, while home boss Mark Jones also has selection woes.
Leading scorer Martin Rose and influential midfielder Gareth Phillips are both suspended, with the number nine shirt likely to be handed to either Drew Fahiya or Daniel Thomas.
In Sunday's other game, Bangor City host Porthmadog in the first game of a festive double header.
"You look at all the derbies over Christmas and think the teams above us are sure to drop points, so if we could pick up six points we’d be right bang in there," says City manager Nev Powell.
"But it’s going to be far from easy against Porthmadog, who have won at Carmarthen and drawn with TNS recently, and are battling for points near the bottom."
The visitors are without suspended former Citizens' striker Paul Roberts, but Bangor-based skipper Ryan Davies is fit to return.