The Citizens play their final match at a ground which has been their home since 1920 and has hosted illustrious opponents including Napoli, Atletico Madrid, Manchester United and Liverpool.
While the game is sure to be an emotion-packed occasion, Powell is confident his players will rise to the occasion.
"It will be a big day for everyone concerned, but for the players it will be a case of staying focused on the job in hand which is to get three points," said the Citizens chief to the Daily Post.
"I’m sure they will do that. We want to give Farrar Road the send-off it deserves. There will be a full house and the last time that happened we won the league (in April).
"Farrar Road has been a very special ground over the years and we want to make sure that in 50 years time the history books will show the last match played here ended in a Bangor victory."
But Powell is not under-estimating the visitors: "Prestatyn are a good side," he stressed. "They’ve lost Lee Hunt, Jack Lewis and Kai Edwards this season, but are still a strong team.
"We’ve got two really big games coming up against them. We’ll be looking for six points to keep us in a strong position and they still need points to make sure of a place in the top six, so there’s a lot at stake."
City will be without suspended midfielders Neil Thomas and Michael Walsh, but welcome back defender Dave Morley.
Meanwhile, visiting player-manager Neil Gibson is happy for his side to be regarded as bit-part players.
"I’m more than happy to take second billing," said Gibson. "You can’t dismiss 91 years of heritage and it will be an emotional occasion.
"This could be the wrong time to be coming up against Bangor as they will be determined to leave Farrar Road on a high note.
"We will make a small show of gratitude ourselves before the game, but then we have to focus on the match and it’s a hugely important one for us as we are determined to finish in the top six before the split."
The Seasiders will have to cope without experienced midfielder Gareth Wilson, who is suspended, but striker Steve Rogers returns from injury and could make his 300th Welsh Premier appearance.